Effective April 1, 2026, the MB/ON Poison Control Centre Acetaminophen Toxicity Protocol has been updated. The new Provincial Treatment of Acetaminophen Toxicity will go live, and the approved documents listed below will be posted at Document Library – Provincial Documents.

• 600.105.121-OS Acute Acetaminophen Toxic Ingestion Adult or Pediatric Provincial, Provincial Order Set
• 600.105.121-OSR-01 Management of Acetaminophen Toxic Ingestion in Adult and Pediatric Patients: Supplementary Resource to Acetaminophen Toxic Ingestion Order Set
• 600.105.121 Management of Acetaminophen Toxic Ingestion in Adult and Pediatric Patients

Recommendations/Action Required:

• Adult Acetylcysteine SH-SS Drug Monograph (date April 2026)
• Pediatric Acetylcysteine SH-SS Drug Monograph (date April 2026)
• 600.105.121-OS Acute Acetaminophen Toxic Ingestion Adult or Pediatric Provincial, Provincial Order Set
• 600.105.121-OSR-01 Management of Acetaminophen Toxic Ingestion in Adult and Pediatric Patients: Supplementary Resource
• 600.105.121 Management of Acetaminophen Toxic Ingestion in Adult and Pediatric Patients
• SH-SS Antidote List (date April 2026)

Submitted by: Tamara Burnham, Collaborative Practice Lead