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Please be advised the following monographs have been updated on the Drug Monographs page. For IV Parenteral Drug Manual holders, please add/replace/discard as indicated.

REPLACE ADULT Monograph:
Discard the old monograph, PRINT (using the hyperlink) & replace with the new monograph in the Adult Parenteral Drug Monograph Manual as listed below:

Medication/TopicApproved Changes
ampicillinReconstitution: Added 1g vials of Auro and Eugia brands NOT MINI BAG PLUS compatible
caspofunginAvailable as: Added CANCIDAS (Merck brand) and Juno brand, Fresenius Kabi brand: Store at room temperature.
Reconstitution: Added Table
IV Intermittenet: Added Table
Max/Single Daily Dose increased to 150mg
DAPTOmycinAdded: Juno Brand
desmopressionAdded: Cushings Diagnostic Test, hyponatremia
Compatability: Added Unknown compatibility with Ringer’s lactate and D5W
dextroseIV Infusion: Changed 500mL to 400mL D50W
DOPamineSoft Low Dose Limit: Decreased to 0.5mcg
IV Infusion: Added Increase by 1 to 5 mcg/kg/min every 10 minutes
enoxaparinOther Names: Added Redesca
Available As: Added 150mg PFS
Dosage: Under Non STEMI/unstable angina patients (regardless of age), maximum dose increased to 150 mg and added Exact dosage will depend if using multi dose vial or pre-filled syringes, and if the CrCl is less than 30 mL/min give daily,
Under STEMI (with te-necteplase) patients less than 75 years old: Added dose banding table. Pulmonary Embo-lism (PERT protocol)
Maximum single subcutaneous dose 150 mg
Additional Notes: Updated
EPINEPHrineDosage: Hypotension refractory to dopamine/dobutamine: Added Increase by doubling the dose (or by 0.02 mcg/kg/min) every 3 to 15 minutes until desired effect
Bradycardia: Added Initial 2 to 10 mcg/minute. Usual range 8 to 40 mcg/minute
esmololAdditional Notes: Limited data for use beyond 24 hours
fentaNYLCompatability: Added Ringers Lactate
Ferric DerisomaltoseGeneric Name changed from iron isomaltoside to Ferric Derisomaltose
Dosage: Updated Table
flumazenilAdded: Contact the Manitoba/Ontario Poison Control Centre at 1-855-776-4766
fondaparinuxNew Monograph
fosphenytoinDosage: Added mg
furosemideAdministration Policy: Added IM Injection
IV Infusion changed 20mg/hour to 40 mg/hour
IV bolus maxium changed from 20mg/minute to 40mg/minute
gentamicinIV Intermittent: Dose changed 100mL to 100mg
glucagonDosage: Removed beta blocker or calcium channel blocker overdose and anaphylaxis sections
inFLIXimabIV Intermittent: Added 0.2 micron filter
ketamine LOWDosage: IV bolus/IV intermittent changed 0.6mg/kg to 0.5mg/kg
Dosage: IV infusion changed 0.15mg/kg/hour to 0.25mg/kg/hour
metoprololDosage: Updated Acute treatment of arrhythmias section
pantoprozoleIV intermittent: Added JAMP brand NOT MINI BAG PLUS compatible
piperacillin-tazobactamReconstitution Dilution Administration: Added 4.5 g vials of Auro and Eugia brands are NOT MINI BAG PLUS compatible
protamine sulfateDosage: Added maximum of 50mg protamine per dose
SUFentanilIV Infusion: Added non-PVC
sugammadexUpdated precautions and additional notes

Submitted by: Cécile Dumesnil, Manager – Pharmacy
For more info. contact: 204-371-5952 or

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