Successful management of sepsis is time sensitive, timely intervention may be lifesaving.

To provide prompt administration when following the Sepsis and Septic Shock Standard Orders, piperacillin / tazobactam Injection 4.5 g in NaCl 0.9% pre-mixed bags will be available at BRHC, BTHC and PDGH / PRHC. Pre-mixed bags should be prioritized for loading doses only. Fresenius Kabi compounded bags are stable for 28 days and may be kept at room temperature. Occasionally, when product is nearing the Beyond Use Date, stock may used for indications outside of the Sepsis protocol to prevent waste.

Vials of piperacillin / tazobactam 4.5 g will be available for use with all other indications. Vials are compatible with Mini-bag Plus.

Piperacillin / Tazobactam Injection 3.375 g in NaCl 0.9% pre-mixed bags, will not be available. This will align with other SDO in Manitoba where vials are currently the sole source of piperacillin / tazobactam 3.375 g. Any remaining supply of the 3.375 g bags will not be replaced once depleted.

Thank you for your support in ongoing efforts to manage drug supply issues.

For questions, please contact your site pharmacy Or contact Rizwan Ahmed or Libby Gair

Submitted by: Rizwan Ahmed – Regional Pharmacy Director